The Sonic Hedgehog Pathway Mediates Carbamylated Epo Enhanced Proliferation and Differentiation of Adult Neural Progenitor Cells
نویسندگان
چکیده
Lei Wang, Zheng Gang Zhang, Sara R. Gregg, Rui Lan Zhang, Zhongxian Jiao, Yvonne LeTourneau, Xianshuang Liu, Yifan Feng, Jens Gerwien, Lars Torup, Marcel Leist, Constance Tom Noguchi, Zhi-Yong Chen, Michael Chopp Departments of Neurology, Henry Ford Health Sciences Center, 2799 W. Grand Boulevard, Detroit, Michigan 48202; Department of Physics, Oakland University, Rochester, Michigan 48309; Drug Metabolism, H. Lundbeck A/S, 2500 Valby, Denmark; Neuropharmacology, H. Lundbeck A/S, 2500 Valby, Denmark; Department of Biology, University of Konstanz, D-78457 Konstanz, Germany; Molecular Cell Biology Section Laboratory of Chemical Biology NIDDK, NIH, Bethesda, Maryland 20892 Running title: CEPO enhanced neurogenesis of adult neural progenitor cells Address correspondence to: Zheng Gang Zhang, MD, Ph.D, Department of Neurology, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, Tel: 313-916-5456; Fax: 313-916-1318; Email: [email protected]
منابع مشابه
The Sonic hedgehog pathway mediates carbamylated erythropoietin-enhanced proliferation and differentiation of adult neural progenitor cells.
Carbamylated erythropoietin (CEPO), a well characterized erythropoietin (EPO) derivative, does not bind to the classical EPO receptor and does not stimulate erythropoiesis. Using neural progenitor cells derived from the subventricular zone of the adult mouse, we investigated the effect of CEPO on neurogenesis and the associated signaling pathways in vitro. We found that CEPO significantly incre...
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